Eculizumab improves fatigue in refractory generalized myasthenia gravis

from Quality of Life Research at on March 23, 2019 at 01:42PM Abstract Purpose To evaluate the effect of eculizumab on perceived fatigue in patients with anti-acetylcholine receptor antibody-positive, refractory, generalized myasthenia gravis (MG) using the Quality of Life in Neurological Disorders (Neuro-QOL) Fatigue subscale, and to evaluate correlations between improvements in Neuro-QOL Fatigue […]

Measuring Survival Benefit in Health Technology Assessment in the Presence of Nonproportional Hazards

from Value in Health at on March 23, 2019 at 10:33AM Publication date: Available online 23 March 2019 Source: Value in Health Author(s): Giles Monnickendam, Mingshu Zhu, Jan McKendrick, Yun Su Abstract Background Proportional hazards (PH) is an assumption often made by researchers, despite evidence of nonproportionality in a significant proportion of clinical trials. […]

A review of attitudes towards the reuse of health data among people in the European Union: the primacy of purpose and the common good

from Health Policy at on March 22, 2019 at 01:30PM Publication date: Available online 21 March 2019 Source: Health Policy Author(s): Lea L. Skovgaard, Sarah Wadmann, Klaus Hoeyer Abstract Health data are used for still more purposes, and policies are enacted to facilitate data reuse within the European Union. This literature synthesis explores attitudes […]

Family and Caregiver Spillover Effects in Cost-Utility Analyses of Alzheimer’s Disease Interventions

from PharmacoEconomics at on March 22, 2019 at 12:21PM Abstract Background and objective Alzheimer’s disease or dementia can impose a significant burden on family and other informal caregivers. This study investigated how the inclusion of family/informal caregiver spillover effects in a cost-utility analysis may influence the reported value of Alzheimer’s disease/dementia interventions. Methods We […]

Cross-cultural adaptation and measurement properties of the Nepali version of the DASH (disability of arm, shoulder and hand) in patients with shoulder pain

from Health and Quality of Life Outcomes at on March 21, 2019 at 05:06PM Patient-reported outcome measures (PROMs) are important tools in both clinical practice and research. However, no upper extremity PROM to assess physical disability is available in Nepali. The most commonly us…

Remote Monitoring of Patient-Reported Outcomes in Ulcerative Colitis: A Prospective Real-World Pilot Study

from PharmacoEconomics – Open at on March 21, 2019 at 03:22PM Abstract Introduction The 6-point version of the Mayo score relies on two patient-reported outcomes (PRO2): stool frequency and rectal bleeding. We assessed the feasibility and acceptability of remote online PRO2 reporting for golimumab-treated ulcerative colitis (UC) patients. Patients and Methods This was a […]